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6.2 Linking GSH/GSSG to Transcriptomic and Proteomic Regulation Transcriptomic and proteomic data can connect metabolite changes to functional modules: GCLC/GCLM/GSS for synthesis, SLC7A11 for substrate acquisition, GSR/GPX/GST for regeneration and use, pentose phosphate pathway enzymes for NADPH supply, and NRF2-KEAP1 signaling for coordinated antioxidant adaptation

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Consistent with this observation, decreased TNF-stimulated IB- phosphorylation was observed in hepatocytes with elevated GSSG levels

In the PD model, DR-AB, an antibody that targets the DR region of the NKA- subunit, disrupts the cytoplasmic interaction between NKA-1 and Parkin, promotes Parkin translocation to mitochondria, and enhances mitochondrial autophagy

T.CelestinoI.CoppoL.HolmgrenA.et al