glutathione peroxidase 1 heme Oxygenase-1 Signaling and Redox Homeostasis in Physiopathological Conditions GPX1 (Glutathione Peroxidase, GSHPx) Gene

Chen, Y., Yi, X., Wei, X

Feng, Y., Madungwe, N

Intracellularly, the Fenton reaction is limited, in part, by the lack of free transition metals in cells, but may play a role in oxidative damage after ischemia-reperfusion or under other oxidative stress conditions that involve accumulation of high levels of intracellular hydrogen peroxide and liberation of Fe 2+ from intracellular storage sites (115, 288)

Given these metabolic observations and the previously identified differential expression of several proteins involved in cholesterol biosynthesis and fatty acid metabolism, we sought to investigate the impact of MATi treatment on the hepatic lipidome via an untargeted lipidomic analysis

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