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Human evidence is still limited, so a medical evaluation and a holistic care plan matter most

The treatment-policy estimand is closer to intention-to-treat: it estimates the effect regardless of whether participants stayed on treatment or used rescue therapies

In addition, the PRNT50 was calculated before and after challenged

The note must show ruled-out focal patterns and a plan to evaluate causes

A copy of a separate letter from Carol's private consultant sent to her GP in March, however, advises giving her two injections a week, alongside folic acid and vitamin D, with a review in June following blood tests