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In addition to the leak and pore pathways, there is also the unrestricted (or apoptotic) pathway, where severe damage to the gut mucosa results in death of epithelial cells and permits unrestricted paracellular transport of large molecules and bacteria

19 Recognising gout and initiating effective treatment early in the clinical course is essential for addressing these disparities and the associated impact on other aspects of life, e.g

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(3) Bilic I, Zoricic I, Anic T, Separovic J, et al