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Its been used globally for over 60 years and is considered safe for long-term use in most patients, including non-diabetics using it preventively

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Ischemic Stroke (ICD-10 codes, I63, G45) comprises patients who had undergone at least one brain CT or MR imaging test within 30 days from the date of diagnostic code registration

"Therapeutic" doses of thiosulfate (150 mg/kg according to these authors) would elevate plasma concentrations about 100 times