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Although coenzyme Q10 (CoQ10) is an antioxidant that has been shown to enhance the activity of complex I and II in the electron transport chain, a meta-analysis reported that CoQ10 supplementation did not slow down the functional decline of PD patients, nor did it provide any symptomatic improvement ( in vivo and in vitro

doi: 10.3389/fphar.2024.1496661 Received 15 September 2024 Accepted 24 October 2024 Published 01 November 2024 Volume 15 - 2024 Edited by Ming Xu, Shimonoseki City University, Japan Reviewed by Aziz Eftekhari, Ege University, Trkiye Ziyi Wang, Johns Hopkins University, United States Updates Copyright 2024 Wei, Li, Li, Zeng, Quan, Leng, Chang, Bai, Bian and Hou

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In a randomized controlled study, melatonin improved sleep quality and morning alertness in aging patients with primary insomnia [244]

Critically, niacinamide does not share the cobalt-corrin structure that appears to be involved in the problematic interaction between B12 and tirzepatide