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This genotype is generally associated with typical or slightly lower endogenous IGF-1 production, which may result in a more modest anabolic response to growth-factor signaling

doi: 10.3390/genes12091305 45 HeQLiuMHuangWChenXZhangBZhangTet al

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In contrast to glutathionylated substrates, the reduction of specific, non-glutathionylated protein disulfides such as Escherichia coli ribonucleotide reductase requires the second cysteine residue of active Grx 10,17,27,28