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Administration of VGB4 led to the regression of 4T1 murine MCT growth through decreased expression of p-VEGFR1 and p-VEGFR2 and abrogation of ERK1/2 and AKT activation followed by considerable decrease of tumor cell proliferation (Ki67 expression) and angiogenesis (CD31 and CD34 expression), induction of apoptosis (increased p53 expression, TUNEL staining and decreased Bcl2 expression), and suppression of metastasis (increased E-cadherin and decreased N-cadherin, NF-B and MMP-9 expression)

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Florey L (1966) The endothelial cell

The combination of pro-GA and erastin induces ferroptosis in glioblastoma cells To elucidate the mechanism underlying the antiproliferative effects of the pro-GA and erastin combination, we evaluated the impact of the ferroptosis-specific inhibitor Ferrostatin-1 (Fer-1) on U87MG cells and GSC subjected to combination therapy