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These benefits are crucial, and interestingly, in a reversal of long-held beliefs, emerging evidence challenges the conventional use of CoQ10 as ubiquinol, with the most recent research indicating that CoQ10, as ubiquinone, is more effective for cardiovascular health than its reduced form, ubiquinol

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However, long-term use of very high doses (exceeding 5 mg per day) may pose certain risks, such as masking the early hematological signs of vitamin B12 deficiency, thereby potentially delaying the diagnosis of its neurological complications (69)

CL, plasma clearance