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They discovered that depleting the iSPNs of TrkB signalling leads to increased striatal dopamine due to an increase in the number of dopaminergic cells in the midbrain dopaminergic areas switching from a low dopamine-producing state to a high dopamine-producing state, resulting in striatal neuron vulnerability and motor dysfunction

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A further mycotoxin possibly contributing to leg weakness is cyclopiazonic acid produced by Aspergillus and Penicillium

If the changes of GSTP1 protein expression or activity can be controlled, thereby increasing the ferroptosis effect of radiotherapy on lung tissue tumors, while reducing radiation damage to normal lung tissue, it has extremely important medical significance for the treatment and prognosis of thoracic tumor patients