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EEG during spells was without epileptic discharges, metabolic investigations and QTc were normal, and whole-exome sequencing confirmed biallelic pathogenic TANGO2 variants

They can provide relief but often come with serious side effects like infections, weight gain, mood swings, and bone loss

Acquisition parameters were: 1.3 s acquisition time, 114 k size of FID, and a relaxation delay (D1) of 15 s

Clinical definitions MS active disease was defined as a clinical attack and/or, at least, one gadolinium enhanced lesion (GEL) in T1-weighted MRI, and/or a new lesion in T2-weighted MRI

Additionally, mild intercellular edema and vacuolization of brain matrix were displayed accompanied with mild higher reactive glial cell infiltrates compared to the control groups