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Nonalcoholic fatty liver disease (NAFLD), viral hepatitis, and alcohol consumption are risk factors for hepatocellular carcinoma (HCC), which accounts for approximately 90% of all liver cancers [2,3,4]

Both loss and gain of functions have been proposed for mutant TDP-43 and mutant FUS, whereas gain of a toxic function is the preferred mechanism associated with mutant SOD1

NAD+: Supporting Cellular Energy and Longevity NAD+ (nicotinamide adenine dinucleotide) is a molecule present in every cell of the body and plays a central role in energy production and mitochondrial function

Gels were pre-run for 30 min to allow the ascorbate, present in the carrier buffer, to enter the gel prior to the application of the samples (Mittler and Zilinskas 1993)

Separation was conducted at a constant temperature of 30 C using a mobile phase of 5% (v/v) acetonitrile, 0.05% (v/v) trifluoroacetic acid, and 0.1 M sodium perchlorate at a flow rate of 0.5 mL/min