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A rigorous study found that G-CSF use is associated with lower all-cause mortality in patients receiving chemotherapy, especially in those on intensive dosing schedules (Lyman 2013)

doi:10.1186/s12958-018-0323-4 [51] Venkatesan P

The aspirin group had more adverse events compared with the placebo group (hemorrhage, 2.0% vs 1.2%

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In addition, various interactions such as genotype and environment should be considered and, while many factors mentioned above may be challenging to control (weather, shed location, hen age etc.), others can be manipulated easily (management including egg handling and vaccination) to achieve the desired outcomes (Singh et al., 2009)