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Notably, ANGII-induced left ventricular hypertrophy and remodeling occurred both in the presence (Ichihara et al., 2001) or absence (Matsumoto et al., 2013) of hypertension, suggesting that hypertension may not be the primary mechanism by which ANGII induces cardiac remodeling

When metallodrugs bind to channel proteins, the ion channel activities can be modulated, such as Zinc, which can modulate NMDA receptors (Lee et al., 2023)