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This section briefly introduces the mechanisms of action of these different NAD types and highlights drugs successfully applied in clinical settings (Fig

Walsh MC, Morris BH, Wrage LA, Vohr BR, Poole WK, Tyson JE, Wright LL, Ehrenkranz RA, Stoll BJ, Fanaroff AA, et al

Are there clinical features of liver disease, myeloproliferative disorder (e.g., blood film changes of unexplained cytopenia, thrombocytosis, or leukocytosis), or another cancer (e.g., cachexia, constitutional symptoms fever, weight loss, night sweats)

Targeting specific aspects of mitochondrial reprogramming, such as the activation of alternative metabolic pathways and changes in mitochondrial apoptosis mechanisms, may become key to enhancing the efficacy of existing therapies and developing new treatments

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