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Advanced techniques like CRISPR gene-editing technology have further enhanced the precision of in vivo models, allowing the replication of specific mutations linked to AD (Zeiss, 2020)

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In this study however, the weight loss efficacy and tolerability profile of davalintide was not superior to pramlintide, and was inferior to the pramlintide/metreleptin combination, thus resulting in deciding to halt further development of davalintide

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