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However, it has been suggested that LC found in red meat, is what promotes atherosclerosis and that there may be a connection between eating red meat and a higher risk of cardiovascular disease [2]

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The stabilization of HIF1 leads to the up-regulation of HIF1 target pyruvate dehydrogenase kinase-1 (PDK1), which phosphorylates and inhibits activity of pyruvate dehydrogenase, an enzyme involved in TCA