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Carf, A., Bernabei, R., Landi, F

As an autoimmune condition, Hashimotos can increase systemic inflammation and affect nerve sensitivity, which may worsen existing nerve pain or make the nervous system more reactive

Several flavonoids such as quercetin, chrysin, luteolin, kaempferol, myricetin, and isorhamnetin are potent inhibitors of xanthine oxidase (Nagao et al., 2014), and therefore decrease the risk of oxidative stress-induced diseases

Several other HDACis have been tested in iPSC-derived FRDA neurons, including resveratrol (a polyphenol which also acts as a sirtuin activator) and nicotinamide [48]

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