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Despite the significant improvements in target discovery and drug design efficiency through the integration of multi-omics data, bioinformatics analysis, NP, and MD simulation in cancer drug development, the application still faces multiple limitations and challenges

Sequence design of NADs Typically, NADs are designed and screened based on the pathogenic genes of specific diseases

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Similarly, no dose adjustment is needed in mild (Child-Pugh A) or moderate (Child-Pugh B) hepatic impairment, though it is contraindicated in severe hepatic impairment (Child-Pugh C)