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Cadmium, environmental exposure and health outcomes

Therefore, this narrative review navigates into the intricate role of TRP metabolism in insomnia and its psychological and neurological comorbidities, particularly cognitive dysfunction, depression, anxiety, stress, traumatic brain injury (TBI), chronic pain, and substance abuse

doi:10.3390/biomedicines11010240

An interesting study demonstrated that Nrf2 has detrimental effects on the heart by promoting ferroptosis during myocardial autophagy deficiency (100)

Beyond classical antioxidant enzymes, dysregulation of multiple OS-related proteins and pathways has been reported in MS, including peroxiredoxin (PRX), an enzyme critical for reducing H 2 O 2 whose dysregulation may impair the cellular ability to handle peroxides (Voigt et al., 2017