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BO-653 was able to suppress hepatitis C replication (Yasui et al., 2013)

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These findings establish protein farnesylation as a central coordinator of AT function, with dysregulation leading to metabolic disease manifestations including impaired glucose uptake, altered lipid storage, and disrupted adipokine secretion ( Table 5 )

Diagnosis The definitive diagnosis of IPF requires: (a) the exclusion of other defined clinical entities or diffuse parenchymal lung diseases of known cause (environmental or occupational exposure, connective tissue diseases, drug toxicity) and (b) the presence of a histological pattern of UIP in the examination of lung tissue obtained by surgical lung biopsy, or radiological evidence of a UIP pattern on the high resolution computed tomography (HRCT), or both

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