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The activation of NRF2 by this mechanism enhances the transcription of genes involved in antioxidant defense and cystine/glutamate exchange, particularly those coding for components of the xCT antiporter (such as SLC7A11), which imports cystine in exchange for glutamate

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For example, someone experiencing a severe asthma attack or a relapse of multiple sclerosis might receive IV steroids to rapidly reduce the inflammatory response and bring symptoms under control

Among them, DNL201, a CNS-penetrant LRRK2 inhibitor, has been shown in preclinical studies to effectively reduce LRRK2 activity and restore lysosomal function

Nitric oxide in the normal kidney and in patients with diabetic nephropathy