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More recently, it has been suggested that this may be due in part to the suppression of P-selectin expression in the vascular endothelium mediated by constitutive, eNOS dependent sGC activation (136)

for example, due to the high availability of extracellular cysteine secreted from surrounding bone marrow stromal cells, chronic lymphocytic leukemia cells can actively import cysteine from the extracellular environment (Zhang et al., 2012)