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Because activated CD8+ T-cells depend on sustained glycolysis, excess extracellular lactate disrupts lactate efflux, leading to intracellular acidification and metabolic dysfunction that blunt T-cell activity within the GBM TME

PMID: 21061363

Also, brain oxidative stress biomarkers, including brain malondialdehyde (MDA), reduced glutathione (GSH), nitric oxide (NO), superoxide dismutase (SOD), brain-derived neurotrophic factor (BDNF) as well as heme oxygenase-1 (HO-1) were measured

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Additionally, the vitamin antioxidant literature is mixed: a small, randomized ascent to Everest Base Camp suggested lower Lake Louise scores and higher SpO 2 with vitamins C/E plus lipoic acid, whereas a larger placebo-controlled expedition to 5200 m found no preventive benefit from oral antioxidants