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has found that exosomes derived from PD-1 inhibitor-treated macrophages exerted a pro-senescent effect on cardiomyocytes, with miR-34a-5p identified as an exosomal transfer RNA (Xia et al., 2020)

Exclusion criteria in studies typically include Wilson's disease, copper allergy, and pregnancy due to insufficient data in those populations

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Notably, BAY-876SU056 combination treatment in this regimen seemed to be well tolerated in WT mice, as body weight change and histology of pathologically examined organs (liver, lung and kidney) were indistinguishable between vehicle and combination treatment cohorts (Extended Data Fig