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g , IB analysis of indicated proteins in HCT116 cells treated with SMART1, in combination with increasing concentrations of Smurf1-L or Poma (0.5 M, 5 M, 50 M) for 12 hours

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This reduction step occurs via oxidation of GSH to GSSG, and the GSSG is subsequently reduced back to GSH in the body via the enzyme glutathione reductase and NADPH 591

Upregulation of oxidative mitochondrial metabolism is an accepted method of resistance to other therapeutic interventions in various diseases, such as pancreatic cancer and acute myeloid leukaemia 67,68