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323,324 The influential role of ALOX12, ALOX15, and 12-HETE on diabetes progression is also correlated with NOX (nicotinamide adenine dinucleotide phosphate oxidase)-mediated endoplasmic reticulum stress, TRPV1 activity, and MAPK signaling, ultimately leading to cell apoptosis

Vehicle stability determines whether the active remains evenly distributed and bioavailable throughout the preparations shelf life

GtGGT is considered the most halotolerant, as it retains more than 90% of its hydrolytic activity in 4 M NaCl, followed by BsGGT retaining 86% of its hydrolytic activity at 3 M NaCl, while EcGGT lost 90% of its hydrolytic activity at the same salt concentration (Wada et al., 2010

Lysosomal dysfunction might play an important role in the development of various diseases, including tumors 14,15,16 , neurodegenerative diseases 17,18,19 , inflammatory diseases 20,21,22 , and cardiovascular diseases 23,24,25 (Table 1)