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Carnitine supplementation therapy to patients with clinical symptoms such as hepatic encephalopathy or severe painful muscle cramps in cirrhotic patients are very effective

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OTC deficiency certainly qualifies as a severe metabolic disorder, as episodes of nausea and vomiting are generally accompanied by profound neurological dysfunction, including ataxia, altered mental status, and/or psychosis, which untreated can be fatal

Furthermore, similar to regulations on other stimulants like tobacco and alcohol, consideration should be given to imposing additional taxes on EDs to discourage their purchase