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SKU: 79133304487
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Description

Front Cardiovasc Med 2021;8

2-[[[(4-Methyl-2-pyridinyl)amino]carbonyl]amino]-N-(2,4,6-trimethylphenyl)-6-benzothiazolecarboxamide

Conclusion 6-Paradol rescued dopaminergic neurons and improved muscular function against rotenone-induced neurotoxicity, effects that could be attributed to inhibition of neuroinflammatory axis (HMGB-1/TLR4/NFB/TNF-) and suppression of necroptotic signaling cascade (TNFR-1/RIPK1/RIPK3/MLKL), along with enhancement of mitochondrial biogenesis via stimulation of PPAR/PGC1/TFAM axis and attenuation of oxidative stress