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A synergy between mechanosensitive calcium- and membrane-binding mediates tension-sensing by C2-like domains

Hence PDI proteins play a critical role in regulating the intracellular redox state, redox signaling, and in preventing protein misfolding and/or aggregation (Wang et al., 2015)

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Other therapies that have been utilized include corticosteroids, acetazolamide, mannitol, glycerin, topiramate, and therapeutic lumbar puncture.71,73,77 There is a report of the use of mannitol and acetazolamide together with the suspension of ATRA to decrease the CSF pressure thereby improving the headaches, diplopia, nausea and vomiting in two days and improvement of papilledema in seven days.78 Topiramate, an anticonvulsant and carbonic anhydrase inhibitor, may also be used in cases not responsive to acetazolamide to improve symptoms.74 The temporary suspension of ATRA/ATO is recommended when there is diagnostic suspicion of PTC in patients with APL

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