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Description

Risk declined until the TMREL of 52 g per day (RR 0.70, 95% UI 0.391.25), then increased until exceeding 99 g per daythe non-drinker equivalence levelbeyond which risk exceeded that of non-drinkers

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conversely, driving substrate entry into the TCA cycle causes ER stress, to an extent nearly as robust as the bona fide ER stressor tunicamycin (Gansemer et al., 2020)