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Chronic sleep deprivation impairs the anabolic processes peptides are trying to stimulate

doi: 10.1016/j.jad.2013.03.029 232 LakhanSEKirchgessnerA

Once the system reaches the brain microenvironment, the over-activated microglia secrete MMP-2, which cleaves the Pep-Mino linkage, triggering the controlled release of minocycline

These steps may make a bigger difference for some people than others it may be more practical to fix your sleep cycle as a college junior than as a new parent but its always going to be faster, safer, and generally better to try making lifestyle changes first