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Anti-IL-5 treatment reduces deposition of ECM proteins in the bronchial subepithelial basement membrane of mild atopic asthmatics

MMN improvement was observed in the absence of robust changes in assessments of clinical severity, though the latter was observed in a larger and more prolonged clinical study

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3, 4, 5 However, it is the paracellular pathway, regulated by the tight junction (TJ), that is responsible for the greatest degree of apical cellcell adhesion, 6, 7 and which has received the most attention for its role in regulating mucosal permeability under normal and pathological conditions