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Further exploration of GHK's role reveals that it may interact with specific biological pathways that govern the release of iron from ferritin

EMBO J 16: 26342645 [DOI] [PMC free article] [PubMed] [Google Scholar] Rong S., Vande Woude G.F

Mechanistically, the microbiota transplant reduced lipopolysaccharide (LPS) levels in the colon, the serum, and the substantia nigra (SN) of the midbrain, suppressing the toll-like receptor 4 (TLR4)/myeloid differentiation primary response 88 (MyD88)/nuclear factor kappa B (NF-B) signaling pathway and its downstream pro-inflammatory products in both the SN and the colon (Zhao et al., 2021)

Finally, key pathways and strategic recommendations for translating GPX4 and ferroptosis research into clinical OA treatments are proposed

Metabolic and biochemical effects of pyrroloquinoline quinone (PQQ) on inflammation and mitochondrial dysfunction: potential health benefits in obesity and future perspectives