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Female or male age-matched mice (712 weeks old) were used for all experiments (unless otherwise stated) and euthanasia was performed by cervical dislocation

In the previous pilot clinical trial, an effect on survival was observed using a dosage of 3 g/day, while in our observational study, the effective dose was 1.5 g/day and, unexpectedly, no effect was observed in subjects treated with 3 g/day

It has been shown that HIF-1 upregulates PD-L1 expression by directly binding to an HRE in the PD-L1 proximal promoter [37,42,90]

Increasing awareness of the documented medical risks associated with anabolicandrogenic steroid misuserather than focusing exclusively on athletic or aesthetic motivationsmay help limit the progression of this growing public-health challenge

The convenience of everyday intake is one of the main aspects supporting its efficacy