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Our model simulations suggest that chronic usage of APAP at recommended therapeutic levels probably does mild liver damage and may be associated with a reduction in GSH levels that compromise antioxidant defense capacity

120 Mechanistically, EGCG treatment enhances STAT5 activation but attenuates STAT3 activation to promote regulatory T cell responses, thus mitigating Th17 responses in these obese models

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Furthermore, oxidative stress and inflammatory pathways triggered by mitochondrial dysfunction also have a crucial impact on aging