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The prediction accuracy assessment indicates that (research question #2) the best achievable mapping accuracy is RMSE of 17.7 [kg m 3 ] (0.486 in log-scale) for SOC density, RMSE of 51.3 [g kg 1 ] (0.574 in log-scale) for SOC content, RMSE of 0.15 [t m 3 ] for bulk density of fine-earth, RMSE of 0.51 for soil pH, RMSE of 8.4 % for soil clay content, and RMSE of 12.6 % for soil sand content, respectively

161 In addition, Cu directly binds to MEK1 with high affinity, which in turn promotes tumor growth by activating downstream ERK1/2 phosphorylation