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Inhibiting zDHHC8 with the small-molecule compound PF-670462 reduces GPX4 palmitoylation, promotes ferroptosis, and enhances CD8 + T cell infiltration, thereby suppressing tumor growth (71)

Formation of active inclusion bodies induced by hydrophobic self-assembling peptide GFIL8

Andersen JV, Schousboe A

In recent years, Ooc platforms have been used to assess the anticancer activity and phytochemical toxicity, for instance, Spatholobi Caulis tannin in cervical cancer (Wang et al., 2018), cis-stilbene glycoside and emodin-8-O--D-glucoside from Polygonum multiflorum in liver cancer (Deng et al., 2025), and panaxatriol from Panax ginseng C.A

At higher doses (500 mg/kg for 8 weeks), it reduced malondialdehyde (MDA) levels and hepatic lipid deposition, suggesting antioxidant and hepatoprotective effects (Arrari et al., 2023)