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10.3389/fphar.2019.01022 48 JoppeK.RoserA

Targeting key enzymes involved in the production of pro-inflammatory mediators represent a different strategy to modulate the immune responses in respiratory diseases

YS: Data curation, Investigation, Visualization, Writing original draft

For instance, CC chemokine receptor-2, vascular cell adhesion molecule-2, and scavenger receptors-A, increase the expression level of PD-L1 that activates PD-1 IC receptor (this restricts the activity of cytotoxic T-cells and further strength the cold tumor environment of GBM) and secretory protein rich in cysteine (SPARC), etc

The connections between nearby pericytes must be weakened, and the basement membrane around them must be deteriorated