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Mitochondrial ROS, particularly O levels, appeared to be elevated in the hippocampal neurons of the Ube3a m-\p+ mouse model, and CoQ10 analogs could attenuate behavioral deficits in these mice [383, 384]

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In a recent issue of Science , Auger et al

In contrast, in patients with congenital hypothyroidism in areas without iodine deficiency treated with 20-60 ug selenomethionine for 3 months (68), Se supplementation was found to reduce serum thyroglobulin

This enhanced bioavailability translates to more consistent neurotransmitter support, particularly during periods of acute stress when catecholamine depletion occurs rapidly