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2025, doi: 10.1007/s12178-025-09990-7

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(2015) demonstrated that MOTS-c administration in mice led to improved metabolic profiles, including reduced weight gain and enhanced insulin sensitivity

8 Contraindications and provisions Many situations limit the use of BV in human therapeutics, including children under five, pregnancy, nursing, infections, post-vaccination, and medically compromised patients (Khalil et al., 2021)

Thus, selective c-Met inhibitors may be a better choice for treatment in patients and more studies are needed to identify the reason for phase II clinical trial failure and the feasibility of using c-Met targeting therapies