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Vitamin B12 safety at a glance Generally safe B12 is generally very safe and has no established upper limit because excess is removed in the urine

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showed that nitration of mitochondrial proteins and depletion of mitochondrial DNA after acetaminophen overdose in mice was due to peroxynitrite formation

The OMM of the por1 mutant has previously been shown to have a limited permeability towards small molecules (Lee et al , 1998) that is not fully complemented by the adaptive upregulation of the TOM pore (Antos et al , 2001

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