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The oncogene KRAS and the loss of LKB1 may drive the upregulation of OXPHOS in cancer [44]

Additionally, ferroptosis-derived ROS can activate the AMPK/ULK1 pathway to initiate autophagy (67), although the precise molecular cascade in LC cells is not fully elucidated

Beyond traditional DNA methylation, SeNPs have been instrumental in expanding our understanding of Ses role in the epigenetic landscape, particularly through the modulation of histone methylation via HMT expression and SAH depletion

FIGURE 1 2.4 Body weight assessment The body weight of all animals was monitored using a digital scale (Kent Scientific, USA) on alternating days throughout the experimental period