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Peak purity analysis revealed a peak purity index for D-Nle-Tyr- Ile-NH-(CH 2 )5-CONH 2 of 0.95 and the internal standard of 0.94

IEEE Power Energy Mag

These exosomes restored the expression of anabolic markers (eg, aggrecan and type II collagen), while inhibiting catabolic enzymes (eg, ADAMTS5 and MMP-13) and inflammatory markers (eg, inducible nitric oxide synthase) in OA-like chondrocytes

S6a,b), but an additive effect of the FORTE constituents stimulated further significant decrease in MMP-1 protein levels compared to collagen peptides alone (Supplementary Fig