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The capacity of both histamine breakdown pathways: HNMT and DAO have been reported to be reduced in those with food intolerances (ref)

doi: Genova ML, Lenaz G

However, both recommendations are tempered by statements that the benefits from duloxetine are limited, and that the treatment is more effective in CIPN due to platinum-based therapies than in CIPN caused by taxanes (Loprinzi, Lacchetti 2020

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The importance of GST A3-3 is shown by inhibiting the enzyme with drugs or by RNA interference of GST A3-3 biosynthesis, treatments which both suppress the hormone production in two steroidogenic human cell lines (Raffalli-Mathieu et al., 2008)