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Furthermore, ACTL6A has been identified as a transcriptional regulator and driving pathways that are of specific benefit to the malignant elements within the tumor 15

Similarly, naringin was reported to alleviate OS and enhance the activity of endogenous antioxidants in streptozotocin-induced DN models, thereby improving behavioral, biochemical, and OS parameters, reducing TNF-/IL-6, and restoring brain/pancreatic tissue integrity ( 4.2 Scavenging of ROS Natural antioxidants, such as polyphenols, flavonoids, and carotenoids, can directly scavenge free radicals and reactive oxygen species, thereby neutralizing their harmful effects

Ebrahimi, S., Rashidy-Pour, A., Vafaei, A

Altogether, these pathways form a tightly integrated network, where oxidative stress, inflammatory signaling, and apoptosis reinforce one another, while regulatory pathways such as Nrf2/HO-1, SIRT1, and -Klotho are suppressed, shifting the cellular balance toward damage and follicular loss

Therefore, can EVs derived from AD-MSCs also play a role in DOP