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Description

HSPA9/mortalin/mtHSP70/GRP75 HSPA9, also known as mortalin, is a constitutive but inducible mitochondrial chaperone involved in multiple functions related to proteostasis and apoptosis

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Key gaps include lack of longitudinal human datasets, validated phenotype biomarkers, optimal timing/duration of interventions, and pediatric safety/riskbenefit evidence, including uncertainty about applying adult antifibrotic drugs in children

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A randomized, double-blind, placebo-controlled, delayed start study to assess rasagiline as a disease modifying therapy in Parkinson''s disease (the ADAGIO study): rationale, design, and baseline characteristics

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