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Research has identified 160 genes that are synergistically regulated by the combined action of IL-17 and TNF-alpha, meaning these two cytokines together produce effects far greater than either one alone

8: McGuire FP, Martinez R, Lenz A, Skinner L, Cushman DM

P65: relA

However, how PPAR prevents PAPR-mediated induction of cardiac FAO, and why combined activation of both PPAR and PPAR causes cardiac dysfunction remained elusive