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Biomarkers of oxidative damage are unchanged or reduced in patients fibroblasts Since the antioxidant defences of the patient fibroblasts appear very efficient, we assessed oxidative damage by measuring MDA, produced by polyunsaturated fatty acids peroxidation, as a marker

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We found that although the mitogen-activated protein kinase pathway is significantly downregulated after mutant KRAS knockdown, these NSCLCs showed increased levels of phospho-STAT3 and phospho-epidermal growth factor receptor, and variable changes in phospho-Akt

Peripheral neuropathy commonly manifests as numbness or discomfort along the nerve pathways in the hands or feet, often referred to as neuralgia

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