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1 Introduction 1.1 Clinical characteristics and therapeutic limitations of Parkinsons disease Parkinsons disease (PD) is the second most prevalent neurodegenerative disorder worldwide, characterized clinically by resting tremor, bradykinesia, rigidity of the limbs and trunk, and postural instability (1)

Regarding autophagy, the two recent findings have introduced complexity

In vivo selective inhibition of mitogenactivated protein kinase kinase 1/2 in rabbit experimental osteoarthritis is associated with a reduction in the development of structural changes

[DOI] [PubMed] [Google Scholar] 217.Klein M., de Quadros De Bortolli J., Guimares F.S., Salum F.G., Cherubini K., de Figueiredo M.A.Z